Frameshift

I didn't even know what a frameshift mutation was before reading this book nor much about Huntington's disease, so I learned from this book. I liked the chronology of how the story was told, with the gripping start in World War II. As with a few of his other books, this had a grandiose hypothesis of evolution that presented a positive look at the future of humanity. I liked the characters, including Amanda, however there was plenty of story here without her and I'd prefer to have read a whole novel about her instead of having her be a minor part of this story. I appreciate the references he sneaks in to pop-culture things, like Columbo. I found it just as exciting to read as the other books by the same author, it might not have been my favorite, but I did enjoy it plenty.