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I couldn't put this book down, but I didn't particularly like it (and I don't think that's what Henderson was going for). At the most granular level, the writing is excellent, and at the broadest, the story resonated with me for personal reasons.
However, I think it could have been told in a far stronger way. I completely understand that with chronic illness - physical and mental - there's rarely a clean and linear resolution, so a tidy ending wouldn't mirror real life. That said, I think she made things harder than necessary for the reader to follow by constantly leaping across timelines (and if she was really tied to that approach, I think the designer should have made it clearer when these jumps were happening - at least in the version I got from the library, the years at the start of each group of chapters were printed far too lightly and were easily overlooked). I also think this is wrenching material and by the end, there was just so much to absorb that it started to lose its impact. Again, I respect that she's likely mirroring her own experience - which I'm sure she and her husband, of all people, would agree has gone on for far too long - but it almost seemed to me like she wrote this book, and made the decisions about it she did, more for herself rather than for a general audience.