Tomie

Male violence is a big theme. It's the men who become too emotional and hysterical (stereotypical traits that are disliked in women), driven crazy by Tomie's beauty. I guess it can be argued that Tomie's responsible for her narcissistic behavior, but her murders often expose male entitlement and their objectification of women.
I guess I could see the idea of the affects of the cycle of abuse on you and the relationships around you. Or a comment on society's unhealthy obsession with possessing and/or destroying beauty.
The art greatly improved as the story went on. Overall, this one didn't sit great with me. Maybe my opinion will change over time. For now though, I liked Uzumaki more